Verification That Mouse Chromosome 14 Is Responsible for Susceptibility to Streptozotocin in NSY Mice

Figure 3

STZ sensitivity at 12 weeks of age in NSY (; black squares), R0 (; black circles), and C3H mice (; white squares). Glucose concentrations and body weight are measured ad lib at days 0, 1, 2, 4, 5, 7, 8, and 14 days after STZ injection. Data are expressed as the mean ± SEM. (a) Blood glucose concentrations. Four NSY mice were dead (one at day 3 and three at days 9–13). Three R0 mice were dead at days 9–13. Because these dead mice showed hyperglycemia before death, the glucose levels after death were reported as 33.34 mmol/l, which is the detection limit of the glucose sensor. , , compared with R0 (one-way ANOVA with post hoc test (Dunnett’s multiple comparison tests)). (b) The percentage of animals free of hyperglycemia. Mice with glycemia higher than 16.7 mmol/l were considered hyperglycemic. , compared with R0 (log-rank test). (c) Body weight changes. Four NSY and three R0 mice were dead (described previously). This figure does not contain the body weight data after death. compared with the basal body weight of R0 and ^†† compared with the basal body weight of NSY (Mann–Whitney U test).

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