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International Journal of Endocrinology
Volume 2018, Article ID 7907512, 5 pages
Research Article

Autoimmune Thyroid Disease and Keratoconus: Is There an Association?

1Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, University of Jordan, Amman, Jordan
2Department of Community Medicine, Public Health and Family Medicine, School of Medicine, Jordan University of Science and Technology, Irbid, Jordan
3Department of Internal Medicine, School of Medicine, University of Jordan, Amman, Jordan
4Division of Ophthalmology, Department of Special Surgery, School of Medicine, University of Jordan, Amman, Jordan

Correspondence should be addressed to Hussam H. Alhawari; oj.ude.uj@irawah.h

Received 18 March 2018; Revised 5 May 2018; Accepted 13 July 2018; Published 31 July 2018

Academic Editor: Jack Wall

Copyright © 2018 Hussam H. Alhawari et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. The association between autoimmune diseases and keratoconus (KC) has been proposed based on previous retrospective studies and case reports. The aim of our study is to investigate whether KC is associated with autoimmune thyroid disease. Methods. A comparative study was conducted on 131 adult subjects from September 2015 to May 2017 at Jordan University Hospital, Amman, Jordan. Subjects were classified into 2 groups: subjects with autoimmune thyroid disease, including Graves’ disease and Hashimoto’s thyroiditis (), and a healthy group for comparison (). Subjects with any other conditions known to be associated with KC were excluded. The diagnosis of KC was based on clinical and corneal topographic findings utilizing the Oculus-Pentacam machine. In addition, TSH and total T4 levels as well as thyroid peroxidase antibodies were measured in all study participants. Antithyroglobulin antibodies, thyroid stimulating immunoglobulin, thyroid ultrasound, and thyroid uptake and scan were also selectively performed in some participants. Results. This study included a total of 131 participants (101 females and 30 males), including patients and controls. In the multivariate analysis, autoimmune disease was not significantly associated with keratoconus (OR = 1.1; 95% confidence interval: 0.3, 3.8; value = 0.353) after adjusting for age and gender. Conclusion. This study did not show a statistically significant association between autoimmune thyroid disease and KC.