Dipeptidyl-Peptidase 4 Inhibitor Sitagliptin Ameliorates Hepatic Insulin Resistance by Modulating Inflammation and Autophagy in ob/ob Mice

Figure 1

Sitagliptin protects the ob/ob mice from body weight gain and glucose-lipid metabolic disorder. Body weight (a) and fasting blood glucose (b) at different periods after sitagliptin treatment (–8). Serum total cholesterol (c) and triglycerides (d) at week 4 after sitagliptin treatment (-6). and versus WT group. and versus ob/ob group. versus week 0. NS: not significant. All data are presented as mean ± SEM.

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