Dipeptidyl-Peptidase 4 Inhibitor Sitagliptin Ameliorates Hepatic Insulin Resistance by Modulating Inflammation and Autophagy in ob/ob Mice

Figure 2

Sitagliptin ameliorates systemic and hepatic insulin resistance. Glucose tolerance test (GTT) and insulin tolerance test (ITT) were performed, respectively, at week 2 (a, b) and week 4 (c, d) (–8). Insulin sensitivity was analyzed by HOMA-IR (e) and fasting serum insulin (f) at week 4 (–6). Western blotting of insulin-stimulated AKT phosphorylation in the liver (g). The level of p-AKT was normalized to that of AKT (). and versus WT group. and versus ob/ob group. All data are presented as mean ± SEM.

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