Dipeptidyl-Peptidase 4 Inhibitor Sitagliptin Ameliorates Hepatic Insulin Resistance by Modulating Inflammation and Autophagy in ob/ob Mice

Table 1

Effects of sitagliptin on body weight, glucose, and lipid metabolism at week 4.

	Parameters		WT	ob/ob	ob/ob + Sita
Glucose metabolism	FBG (mmol/L)		8.13 ± 0.88	11.55 ± 3.49	9.03 ± 2.01
	Insulin (pmol/L)		0.43 ± 0.10	13.14 ± 0.45	5.59 ± 2.65
Lipid metabolism	Blood lipids (mmol/L)	TC	2.64 ± 0.76	5.27 ± 0.58	4.10 ± 0.59
		TG	0.71 ± 0.10	1.28 ± 0.53	0.76 ± 0.20
	Liver lipids (mM/g protein)	Liver TG	5.48 ± 1.76	13.70 ± 3.02	8.01 ± 1.98

FBG: fasting blood glucose; TG: triglycerides; TC: total cholesterol. versus WT group. and versus ob/ob group. –8 mice per group. Data are expressed as mean ± SEM.