A Dipeptidyl Peptidase-4 Inhibitor Suppresses Macrophage Foam Cell Formation in Diabetic db/db Mice and Type 2 Diabetes Patients

Table 1

Characteristics and laboratory data of db/db misty mice and db/db mice at 13 weeks old.

	db/db misty	db/db	value
Number	7	7	−
Food intake (g/day)	3.1 ± 0.1	4.5 ± 0.2	^★
Final body weight (g)	25.4 ± 0.3	43.8 ± 0.6	^★
SBP (mmHg)	106 ± 4	109 ± 4	0.622
DBP (mmHg)	57 ± 3	61 ± 2	0.274
Total-C (mg/dL)	102 ± 3	112 ± 16	0.473
HDL-C (mg/dL)	56 ± 3	63 ± 13	0.573
Triglyceride (mg/dL)	91 ± 3	134 ± 16	^★
Insulin (ng/mL)	0.27 ± 0.03	2.48 ± 0.32	^★
FBG (mg/dL)	107 ± 5	432 ± 26	^★
HbA1c (%)	4.2 ± 0.1	8.3 ± 0.2	^★
OGTT-AUC (mg/dL × hour)	276 ± 3	1215 ± 85	^★

SBP: systolic blood pressure; DBP: diastolic blood pressure; Total-C: total cholesterol; HDL-C: high-density lipoprotein cholesterol; FBG: fasting blood glucose; HbA1c: hemoglobin A1c; OGTT: oral glucose tolerance test; AUC: area under the curve of glucose. Results are presented as mean values ± SEM and analyzed with unpaired -test. vs. db/db misty mice.