Emergence of Pituitary Adenoma in a Child during Surveillance: Clinical Challenges and the Family Members’ View in an AIP Mutation-Positive Family

Table 2

Biochemical evaluation of the somatotrope and prolactin axes in the proband’s sister (case 3).

Date of biochemical evaluation	IGF-1	Normal range	Prolactin	Normal range	GH on OGTT; 0–30–60–90–120–150
November 2008	433	94–506 ng/mL	405	<496 mU/L
August 2009	261	94–506 ng/mL	444	<496 mU/L
February 2010	283	94–506 ng/mL	456	<496 mU/L	1.1–0.35–0.21–0.16–0.83–5.81 μg/L
September 2010	164	94–506 ng/mL	329	<496 mU/L
June 2011	333	94–506 ng/mL	349	<496 mU/L
September 2012	172	94–506 ng/mL	312	<496 mU/L	1.07–0.35–0.22–0.19–0.28–1.05 μg/L
October 2013	253	149–332 μg/L	408	<496 mU/L	7.28–1.65–0.69–0.32–0.27–0.25 μg/L
July 2015	224	149–332 μg/L	365	<496 mU/L	10.56–1.65–0.73–0.38–0.39–0.62 μg/L
December 2016	166	103.3–328.4 μg/L	601	<496 mU/L	4.62–2.10–0.76–0.46–0.22–0.14 μg/L