Positive Association of Metabolic Syndrome with a Single Nucleotide Polymorphism of Syndecan-3 (rs2282440) in the Taiwanese Population

Table 5

Relationship between SDC3 polymorphism (rs2282440) and metabolic syndrome and related risk factors.

	C/C	C/T	T/T
	OR (95% CI)	OR (95% CI)	OR (95% CI)
MetS	1.00 (reference)	0.92 (0.54–1.55)	1.80 (1.01–3.22)
Large WC	1.00 (reference)	1.00 (0.64–1.57)	1.75 (1.04–2.96)
High TG	1.00 (reference)	0.93 (0.56–1.55)	1.20 (0.67–2.13)
Low HDL-C	1.00 (reference)	1.26 (0.74–2.13)	1.84 (1.02-3.32)
High BP	1.00 (reference)	0.78 (0.49–1.24)	1.39 (0.82–2.36)
High FPG	1.00 (reference)	0.87 (0.50–1.52)	1.05 (0.56–1.98)
Obesity	1.00 (reference)	0.88 (0.55–1.4)	1.96 (1.11–3.45)
HOMA-IR group
≥ 75%tile	1.00 (reference)	0.74 (0.46–1.19)	1.31 (0.77–2.25)
hs-CRP group
≥ 75%tile	1.00 (reference)	1.17 (0.70–1.94)	2.00 (1.15–3.51)

Odds ratios were calculated by using multiple logistic regression models for categorical SDC3 genotypes after adjustment for sex, age, smoking, alcohol drinking, and exercise habits. MetS: metabolic syndrome; WC: waist circumference; TG: triglyceride; HDL-C: high-density lipoprotein cholesterol; BP: blood pressure; FPG: fasting plasma glucose; HOMA-IR indicates homeostasis model assessment for insulin resistance; hs-CRP: high-sensitivity C-reactive protein.