The Efficacy and Safety of the Chinese Herbal Formula, JTTZ, for the Treatment of Type 2 Diabetes with Obesity and Hyperlipidemia: A Multicenter Randomized, Positive-Controlled, Open-Label Clinical Trial
Table 2
Changes in the T2D levels, hyperlipidemia levels, obesity levels, and pancreatic islet function levels of participants receiving JTTZ formula and metformin.
JTTZ group
MET group
values: week 12 in the JTTZ group versus MET group
values: change in the JTTZ group versus MET group
Baseline
Week 12
Change from baseline to week 12
values: baseline versus week 12
Baseline
Week 12
Change from baseline to week 12
values: baseline versus week 12
T2D levels
HbA1c (%)
8.26 ± 1.35
7.51 ± 1.44
−0.75 ± 1.32
0.000
8.28 ± 1.33
7.57 ± 1.42
−0.71 ± 1.2
0.000
0.639
0.700
FPG (mmol/L)
9.64 ± 2.59
8.24 ± 2.35
−1.4 ± 2.4
0.000
9.56 ± 2.39
8.21 ± 2.23
−1.33 ± 2.33
0.000
0.865
0.781
2 h PG (mmol/L)
16.76 ± 4.93
14.52 ± 4.73
−2.42 ± 4.53
0.000
17.00 ± 4.72
14.83 ± 4.32
−2.18 ± 4.48
0.000
0.500
0.606
Hyperlipidemia levels
TG (mmol/L)
3.43 ± 2.83
2.79 ± 1.86
−0.64 ± 2.37
0.000
3.18 ± 2.14
2.82 ± 1.91
−0.37 ± 2.18
0.018
0.889
0.227
TC (mmol/L)
5.46 ± 1.24
5.06 ± 1.00
−0.39 ± 0.99
0.000
5.56 ± 1.36
5.21 ± 1.00
−0.36 ± 1.16
0.000
0.147
0.764
LDL-C (mmol/L)
3.21 ± 0.96
2.92 ± 0.73
−0.29 ± 0.79
0.000
3.29 ± 0.90
2.98 ± 0.76
−0.31 ± 0.71
0.000
0.401
0.812
Obesity levels
Weight (kg)
77.82 ± 12.08
75.34 ± 12.05
−2.47 ± 2.71
0.000
76.86 ± 12.06
74.83 ± 12.00
−2.03 ± 2.36
0.000
0.666
0.093
BMI (kg/m2)
28.24 ± 3.31
27.33 ± 3.34
−0.9 ± 0.99
0.000
28.01 ± 3.22
27.27 ± 3.21
−0.74 ± 0.86
0.000
0.844
0.096
Waist circumference (cm)
97.25 ± 8.09
94.73 ± 8.29
−2.52 ± 4.29
0.000
97.47 ± 9.24
94.98 ± 9.03
−2.49 ± 3.86
0.000
0.774
0.946
Hip circumference (cm)
105.05 ± 7.14
102.02 ± 7.23
−3.04 ± 3.86
0.000
105.31 ± 7.36
102.67 ± 7.16
−2.65 ± 3.51
0.000
0.359
0.225
Pancreatic islet function levels
HOMA-IR
1.58 ± 0.72
1.39 ± 0.68
−0.19 ± 0.91
0.005
1.5 ± 0.75
1.35 ± 0.67
−0.16 ± 0.82
0.010
0.626
0.930
HOMA-β
3.73 ± 0.76
3.95 ± 0.76
0.26 ± 0.82
0.000
3.63 ± 0.78
3.91 ± 0.73
0.27 ± 0.87
0.000
0.638
0.752
Data presented as mean ± standard deviation. HbA1c: glycosylated hemoglobin; FPG: fasting plasma glucose; 2 h PG: 2 h postprandial plasma glucose; TC: total cholesterol; TG: triglycerides; LDL-C: low-density lipoprotein cholesterol; BMI: body mass index; HOMA-IR: insulin resistance index; HOMA-β: β cell function index.
