Synergistic Effects of Dantrolene and Nimodipine on the Phenylephrine-Induced Contraction and ACh-Induced Relaxation in Aortic Rings from Diabetic Rats

<div>Effects of a 30 min incubation period with 50 <i>μ</i>M dantrolene, with 50 nM nimodipine, and with both drugs in combination on the endothelial-independent relaxation of aortic rings from control (a) and STZ diabetic rats (b). Aortic rings were precontracted with 0.1 <i>μ</i>M phenylephrine (PHE) before the addition of 1.0 <i>μ</i>m sodium nitroprusside (SNP) to directly relax the vascular smooth muscle. The values shown are the means ± SEM of 6 to 9 animals per group. Note that the drugs, either alone or in combination, did not modify endothelial-independent relaxation in control or STZ diabetic rats.</div>

International Journal of Endocrinology

fig5

Figure 5

Figure 5: Synergistic Effects of Dantrolene and Nimodipine on the Phenylephrine-Induced Contraction and ACh-Induced Relaxation in Aortic Rings from Diabetic Rats 

Figure 5 | Synergistic Effects of Dantrolene and Nimodipine on the Phenylephrine-Induced Contraction and ACh-Induced Relaxation in Aortic Rings from Diabetic Rats 