Synergistic Effects of Dantrolene and Nimodipine on the Phenylephrine-Induced Contraction and ACh-Induced Relaxation in Aortic Rings from Diabetic Rats

Table 3

Effects of a 30 min incubation period with 50 μM dantrolene (D), 50 nM nimodipine (N), and both drugs in combination (D + N) on EC₅₀ and _max values for PHE-induced contraction in control and diabetic rats.

Condition	max (g/mg tissue)	EC50 (nM)
Control none	0.41 ± 0.03	43.2 ± 8.11
Control + D	0.31 ± 0.03	118.72 ± 17.27
Control + N	0.19 ± 0.03	40.74 ± 10.20
Control D + N	0.08 ± 0.01	123.11 ± 34.15
Diabetic none	0.46 ± 0.04	50.83 ± 7.78
Diabetic + D	0.33 ± 0.08	118.73 ± 16.47
Diabetic + N	0.29 ± 0.04	48.71 ± 16.78
Diabetic D + N	0.08 ± 0.01	98.06 ± 34.35

Values shown are the means ± SEM of an average of 6 to 9 animals per group. , when comparing treated and untreated aortic rings of controls. , when comparing treated and untreated aortic rings of diabetics.