Synergistic Effects of Dantrolene and Nimodipine on the Phenylephrine-Induced Contraction and ACh-Induced Relaxation in Aortic Rings from Diabetic Rats

Table 4

Effects of a 30 min incubation period with 50 μM dantrolene (D), 50 nM nimodipine (N), and both drugs in combination (D + N) on EC₅₀ and _max values for ACh-induced relaxation in control and diabetic rats.

Condition	max relaxation, %	EC50 (μM)
Control none	80.66 ± 4.32	1.548 ± 1.197
Control + D	76.42 ± 8.48	0.337 ± 0.126
Control + N	72.87 ± 3.94	0.466 ± 0.176
Control D + N	87.27 ± 3.51	0.121 ± 0.003
Diabetic none	56.46 ± 5.14	0.490 ± 0.200
Diabetic + D	95.71 ± 6.15	0.465 ± 0.231
Diabetic + N	57.57 ± 6.30	0.950 ± 0.414
Diabetic D + N	96.21 ± 7.50	0.115 ± 0.090

Values shown are the means ± SEM of an average of 6 to 9 animals per group. , when comparing treated and untreated aortic rings of diabetics.