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International Journal of Endocrinology
Volume 2018, Article ID 9793850, 6 pages
Research Article

Positive Antithyroid Antibodies and Nonsuppressed TSH Are Associated with Thyroid Cancer: A Retrospective Cross-Sectional Study

13rd Department of Medicine-Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital in Prague, U Nemocnice 1, 128 08 Praha 2, Czech Republic
2Dialectology Center, Institute of Clinical and Experimental Medicine, Vídeňská 1958, 140 21 Praha 4, Czech Republic
3Department of ENT, Surgery of Head and Neck, Na Homolce Hospital, Roentgenova 2/37, 150 00 Praha 5, Czech Republic

Correspondence should be addressed to Jan Krátký; zc.nfv@yktark.naj

Received 12 February 2018; Accepted 9 May 2018; Published 6 September 2018

Academic Editor: Christian-Heinz Anderwald

Copyright © 2018 Jan Krátký et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The relationship between Hashimoto’s thyroiditis (HT) and thyroid cancer (TC) is a controversial topic; it remains unclear if HT acts as a risk factor of TC. The aim of our study was to compare the presence of HT and thyroid function in patients with TC and benign nodules. We analyzed 2571 patients after fine needle aspiration biopsy of thyroid nodule. Totally, 91 patients with primary TC and 182 sex- and age-matched controls were included. Positive antithyroid peroxidase (anti-TPO) and antithyroglobulin (anti-Tg) antibodies were associated with TC (anti-TPO 44% in TC vs. 27% in controls, , anti-TG 35% in TC group vs. 21% in controls, ), and the TC group had significantly higher TSH (median 1.88 mIU/l vs. 1.21 mIU/l, ). Using multiple logistic regression, positive anti-TPO was identified as an independent risk factor (OR 2.21, ), while spontaneously suppressed was a protective factor (OR 0.3, ) against TC. In conclusion, nodules in subjects with positive antithyroid antibodies could be considered to have a higher risk of malignancy. However, based on our results, it is not possible to declare that TC is triggered by HT.