International Journal of Endocrinology / 2019 / Article / Fig 3

Research Article

Glibenclamide-Induced Autophagy Inhibits Its Insulin Secretion-Improving Function in β Cells

Figure 3

Glibenclamide-induced autophagy may inhibit its ability to promote insulin secretion in MIN-6 cells. (a) The different treatments of MIN-6 cells for insulin secretion level; , 1640 vs. 1640 + Glib10; , 1640 vs. 1640 + Glib10 + 3-MA. (b) Statistical results of cell immunofluorescence test. , 1640 vs. 1640 + Glib10. Data shown are mean ± SEM of values from at least 30 cells with triplicate samples. (c) Cell immunofluorescence analysis. MIN-6 cells were stained with an anti-LC3 antibody and observed with a laser confocal microscope (scale bar: 5 μm). (d) LC3 turnover assay and the relative grey density of LC3II/LC3I.

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