Dietary Genistein Could Modulate Hypothalamic Circadian Entrainment, Reduce Body Weight, and Improve Glucose and Lipid Metabolism in Female Mice

Figure 4

Dietary genistein could regulate gene expression in the hypothalamus. (a) The volcano plot graphs: this graph shows the log2 of the fold change in each gene’s expression between the two groups and its -log (p value) from the t-test. The red indicates that the gene is upregulated, whereas the green indicates that gene is downregulated; and (b) heatmap diagram: this diagram illustrates the differential expression of hypothalamic mRNAs in the HF group (n = 3) compared with the HFG group (n = 3). The hierarchical clustering was based on 878 differentially expressed mRNAs. HF: high-fat diet without genistein; HFG: high-fat diet with genistein.

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