Treating Clinically Node-Negative Insular Thyroid Carcinoma without Prophylactic Central Compartment Neck Dissection Is Associated with Decreased Survival Regardless of T Staging and Administration of Radioactive Iodine Therapy: The First Evidence
Table 1
Baseline characteristics of the overall cohort (N = 112).
Characteristics
Overall cohort n = 112
Lob/TT + CCND group N = 44
Lob/TT group N = 68
Age at diagnosis
0.360
Median (range)
58 (21–94)
55 (21–94)
60 (21–88)
<55
45 (40.2%)
20 (45.5%)
25 (36.8%)
≥55
67 (59.8%)
24 (54.5%)
43 (63.2%)
Sex
0.174
Female
65 (58.0%)
29 (65.9%)
36 (52.9%)
Male
47 (42.0%)
15 (34.1%)
32 (47.1%)
Race
0.703
White
87 (77.7%)
34 (77.3%)
53 (77.9%)
Black
15 (13.4%)
5 (11.4%)
10 (14.7%)
Others
10 (8.9%)
5 (11.4%)
5 (7.4%)
Tumor size
0.773
≤4 cm
40 (35.7%)
15 (34.1%)
25 (36.8%)
>4 cm
72 (64.3%)
29 (65.9%)
43 (63.2%)
Multifocal
0.423
No
83 (74.1%)
34 (77.3%)
49 (72.1%)
Yes
19 (17.0%)
8 (18.2%)
11 (16.2%)
Unknown
10 (8.9%)
2 (4.5%)
8 (11.8%)
Extrathyroidal extension
0.038
No
74 (66.1%)
24 (54.5%)
50 (73.5%)
Yes
38 (33.9%)
20 (45.5%)
18 (26.5%)
AJCC 8th T staging
0.465
T1/T2
35 (31.3%)
12 (27.3%)
23 (33.8%)
T3/T4
77 (68.7%)
32 (72.7%)
45 (66.2%)
Surgery of thyroid gland
0.380
Lob
14 (12.5%)
4 (9.1%)
10 (14.7%)
TT
98 (87.5%)
40 (90.9%)
58 (85.3%)
Radiation
0.475
RAI
70 (62.5%)
30 (68.2%)
40 (58.8%)
EBRT
12 (10.7%)
3 (6.8%)
9 (13.2%)
No evidence
30 (26.8%)
11 (25.0%)
19 (27.9%)
Lob refers to lobectomy ± isthmusectomy; TT = total thyroidectomy; CCND = central compartment neck dissection; EBRT = external beam radiotherapy; RAI = radioactive iodine.
