Treating Clinically Node-Negative Insular Thyroid Carcinoma without Prophylactic Central Compartment Neck Dissection Is Associated with Decreased Survival Regardless of T Staging and Administration of Radioactive Iodine Therapy: The First Evidence

Table 3

Type-A multivariate Cox regression models investigating the factors associated with OS and DSS for patients treated with TT (N = 98).

Variables	OS		DSS
	HR (95% CI)		HR (95% CI)
Age at diagnosis
<55	Ref		Ref
≥55	7.794 (1.977–30.724)	0.003	9.541 (1.472–61.830)	0.018
Sex
Female	Ref		Ref
Male	2.698 (1.032–7.056)	0.043	3.408 (0.935–12.421)	0.063
Race
White	Ref		Ref
Black	1.092 (0.234–5.098)	0.911	3.489 (0.601–20.250)	0.164
Others	1.019 (0.218–4.759)	0.981	1.413 (0.266–7.508)	0.685
Tumor size
≤4 cm	Ref		Ref
>4 cm	1.129 (0.411–3.096)	0.815	1.938 (0.508–7.407)	0.333
Multifocal
No	Ref		Ref
Yes	3.984 (1.226–12.947)	0.022	8.837 (1.820–42.913)	0.007
Unknown	3.716 (0.817–16.911)	0.089	3.052 (0.376–24.808)	0.297
Extrathyroidal extension
No	Ref		Ref
Yes	4.264 (1.662–10.940)	0.003	8.427 (2.089–34.003)	0.003
Radiation
RAI	Ref		Ref
EBRT	0.931 (0.198–4.373)	0.928	2.394 (0.430–13.334)	0.319
No evidence	1.392 (0.501–3.869)	0.525	2.720 (0.660–11.214)	0.166
CCND
Yes	Ref		Ref
No	4.175 (1.325–13.158)	0.015	5.087 (1.089–23.751)	0.039