The Association between a 24-Hour Blood Pressure Pattern and Circadian Change in Plasma Aldosterone Concentration for Patients with Aldosterone-Producing Adenoma
Table 1
Demographic and biochemical values in patients with aldosterone-producing adenoma and essential hypertension.
APA (n = 27)
EH (n = 27)
P-value
Age (years)
45.9 ± 11.0
41.6 ± 12.4
0.188
Sex (male/female)
13/14
13/14
1.000
Body mass index (kg/m2)
23.7 ± 3.7
24.5 ± 3.6
0.407
Duration of hypertension (weeks)
153 (58, 330)
156 (46,306)
0.945
Family history of hypertension (yes/no)
15/12
14/13
1.000
Serum potassium (mmol/L)
2.62 ± 0.71
3.62 ± 0.55
<0.001
Serum total cholesterol (mmol/L)
4.64 ± 1.09
4.88 ± 1.12
0.450
Serum triglyceride (mmol/L)
1.25 ± 0.57
1.43 ± 1.32
0.518
Serum HDL-c (mmol/L)
1.24 ± 0.29
1.15 ± 0.25
0.200
Serum LDL-c (mmol/L)
3.02 ± 0.97
3.27 ± 0.99
0.368
Basal PAC (ng/dL)
21.8 ± 6.3
18.1 ± 6.5
0.049
Post challenge PAC (ng/dL)
23.5 ± 7.2
18.5 ± 4.6
0.006
Basal PRA (ng/mL/h)
0.050 (0.040, 0.308)
1.665 (1.052, 3.247)
<0.001
Post challenge PRA (ng/mL/h)
0.058 (0.052, 0.326)
6.887 (4.587, 10.86)
<0.001
Basal ARR
306 (240, 574)
12.9 (8.7, 35.9)
<0.001
Post challenge ARR
339 (219, 670)
2.89 (1.64, 6.75)
<0.001
24-h urine aldosterone (ug/24-hour)
4.92 ± 2.69
3.1 1 ± 1.84
0.019
not normally distributed, data expressed as median ( percentile, percentile) APA, aldosterone-producing adenoma; EH, essential hypertension; PAC, plasma aldosterone concentration; PRA, plasma renin activity; ARR, aldosterone renin ratio, calculated as PAC (ng/dL)/PRA (ng/mL/h)
