A Chinese Family with Familial Dysalbuminemic Hyperthyroxinemia (FDH) due to R242H Mutation on Human Albumin Gene: Reevaluating the Role of FDH in Patients with Asymptomatic Hyperthyroxinemia

Table 1

Parameters of thyroid function and biochemical assays.

	Normal ranges	II-1^+	II-2	II-3	III-1	III-2	III-3	III-4^§	III-5
Age (years)	—	44	41	39	17	12	8	11	5
TT4 (nmol/L)	66–181	132.4	355.6^‡	321.7^‡	122.6	399.1^‡	112.7	391.4^‡	138.3
TT3 (nmol/L)	1.3–3.1	2.3	9.2^‡	7.0^‡	1.9	6.9^‡	1.7	8.9^‡	2.5
FT4 (pmol/L)	12–22	15.27	27.05^‡	29.10^‡	15.06	38.04^‡	12.87	32.08^‡	17.19
FT3 (pmol/L)	3.1–6.8	3.56	7.71^‡	6.15	3.92	8.12^‡	3.39	7.30^‡	5.31
TSH (mIU/L)	0.27–4.2	1.87	2.61	2.38	3.40	3.33	2.54	1.34	2.99
TGAb (IU/L)	0–115	16.76	21.54	41.22	38.43	13.84	43.38	15.22	31.98
TPOAb (IU/L)	0–34	20.58	10.19	7.93	8.28	17.51	9.17	18.97	18.67
TRAb (IU/L)	0–1.58	<0.3	0.42	0.56	ND	<0.3	ND	<0.3	<0.3
ALT (U/L)	<45	61^‡	22	23	15	18	9	12	16
AST (U/L)	<45	37	17	19	13	25	11	16	13
ALB (g/L	34–53	41	39	44	43	45	41	43	43
CREA (μmol/L)	62–115	65	100	78	63	48	56	67	55

Normal ranges of all parameters originate from the corresponding manufactures. ⁺The member labelled as no. 1 of the second generation (II) in the pedigree chart shown in Figure 1 and so on for other family members. ^§The proband. ^‡Elevated results deduced from corresponding normal ranges and so on for other laboratory results. ND: not detected. TT4: total thyroxine, TT3: total triiodothyronine, FT4: free thyroxine, FT3: free triiodothyronine, TSH: thyrotropin, TGAb: antithyroglobulin antibody, TPOAb: antithyroid peroxidase antibody, TRAb: anti-TSH receptor antibody, ALT: alanine aminotransferase, AST: aspartate aminotransferase, ALB: albumin, and CREA: creatinine.