Research Article
Long Noncoding RNA LOC100129940-N Is Upregulated in Papillary Thyroid Cancer and Promotes the Invasion and Progression
Figure 5
Overexpression of LOC100129940-N activates the Wnt/β-catenin signaling. (a) Luciferase assay for TOP/FOP reporters in the indicated cell. . (b) LOC100129940-N promoted nuclear translocation of β-catenin in the indicated cells. (c) The expression levels of LGR5, FN1, VEGFA, SOX9, and CCND1 were increased by the ectopic expression of LOC100129940-N. . (d) The expression of TCF4 in the indicated cells was analyzed by WB analysis. (e, f) Quantification of invading cells and EdU-positive cells in LOC100129940-N-overexpressing cells with silencing of TCF4. .
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