IRF7 Gene Variations Confer Susceptibility to Autoimmune Thyroid Diseases and Graves’ Ophthalmopathy

Table 2

Allele and genotype frequencies of IRF7 SNPs in controls and AITD patients.

SNP	Genotype/allele	Control (%)	AITD (%)		OR	95% CI
rs1061501	AA	344 (44.7)	423 (47.6)
	AG	357 (46.4)	376 (42.3)	0.237	—	—
	GG	69 (9.0)	90 (10.1)
	A	1045 (67.9)	1222 (68.7)	0.590	0.961	0.830-1.112
	G	495 (32.1)	556 (31.3)
rs1131665	AA	752 (97.7)	849 (95.5)
	AG	18 (2.3)	40 (4.5)	0.017	1.968	1.119-3.463
	GG	0 (0)	0 (0)
	A	1522 (98.8)	1738 (97.8)	0.018	1.946	1.111-3.409
	G	18 (1.2)	40 (2.2)
rs1061502	AA	752 (97.7)	851 (95.7)
	AG	18 (2.3)	38 (4.3)	0.029	1.866	1.056-3.296
	GG	0 (0)	0 (0)
	A	1522 (98.8)	1740 (97.9)	0.031	1.847	1.050-3.249
	G	18 (1.2)	38 (2.1)

AITD, autoimmune thyroid disease; OR, odds ratio; 95% CI, 95% confidence intervals.