Research Article
IRF7 Gene Variations Confer Susceptibility to Autoimmune Thyroid Diseases and Graves’ Ophthalmopathy
Table 3
Allele and genotype frequencies of IRF7 SNPs in GD, HT patients, and controls.
| | SNP | Control (%) | GD (%) | | OR (95% CI) | HT (%) | | OR (95% CI) |
| | rs1061501 | | | | | | | | | AA | 344 (44.7) | 281 (47.5) | 0.565 | — | 142 (47.8) | 0.074 | — | | AG | 357 (46.4) | 258 (43.6) | — | — | 118 (39.7) | — | — | | GG | 69 (9.0) | 53 (9.0) | — | — | 37 (12.5) | — | — | | A | 1045 (67.9) | 820 (69.3) | 0.436 | 0.937 (0.796-1.103) | 402 (67.7) | 0.936 | 1.008 (0.823-1.235) | | G | 495 (32.1) | 364 (30.7) | | | 192 (32.3) | | | | rs1131665 | | | | | | | | | AA | 752 (97.7) | 564 (95.3) | 0.015 | 2.074 (1.136-3.787) | 285 (96.0) | 0.132 | 1.759 (0.837-3.698) | | AG | 18 (2.3) | 28 (4.7) | | | 12 (4.0) | | — | | GG | 0 (0) | 0 (0) | | | 0 (0) | | | | A | 1522 (98.8) | 1156 (97.6) | 0.016 | 2.048 (1.127-3.721) | 582 (98.0) | 0.134 | 1.743 (0.835-3.642) | | G | 18 (1.2) | 28 (2.4) | | | 12 (2.0) | | | | rs1061502 | | | | | | | | | AA | 752 (97.7) | 566 (95.6) | 0.034 | 1.919 (1.042-3.535) | 285 (96.0) | 0.132 | 1.759 (0.837-3.698) | | AG | 18 (2.3) | 26 (4.4) | | | 12 (4.0) | | — | | GG | 0 (0) | 0 (0) | | | 0 (0) | | | | A | 1522 (98.8) | 1158 (97.8) | 0.035 | 1.898 (1.036-3.479) | 582 (98.0) | 0.134 | 1.743 (0.835-3.642) | | G | 18 (1.2) | 26 (2.2) | | | 12 (2.0) | | |
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GD, Graves’ disease; HT, Hashimoto’s thyroiditis; OR, odds ratio; 95% CI, 95% confidence intervals.
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