IRF7 Gene Variations Confer Susceptibility to Autoimmune Thyroid Diseases and Graves’ Ophthalmopathy

Table 4

IRF7 genotype and allele distribution in ophthalmopathy or nonophthalmopathy GD patients.

SNP	GD			OR (95% CI)
	Ophthalmopathy	Nonophthalmopathy
rs1061501	—	—	—	—
AA	41 (38.7%)	240 (49.4%)	—	—
AG	52 (49.1)	206 (42.4%)	0.102	—
GG	13 (12.3)	40 (8.2%)	—	—
A	134 (63.2%)	686 (70.6%)	0.035	1.396 (1.023-1.906)
G	78 (32.8%)	286 (29.4%)	—	—
rs1131665	—	—	—	—
AA	104 (99.1%)	460 (97.3%)	—	—
AG	2 (0.9%)	26 (2.7%)	0.128	2.939 (0.687-12.579)
GG	0 (0%)	0 (0%)	—	—
A	210 (98.2%)	946 (97.6%)	0.133	2.886 (0.680-12.253)
G	2 (1.8%)	26 (2.4%)	—	—
rs1061502	—	—
AA	104 (99.1%)	462 (95.1%)	—	—
AG	2 (0.9%)	24 (4.9%)	0.259	2.701 (0.629-11.610)
GG	0 (0%)	0 (0%)	—	—
A	210 (98.2%)	948 (97.5%)	0.265	2.658 (0.623-11.335)
G	2 (1.8%)	24 (2.5%)	—	—

GD, Graves’ disease; OR, odds ratio; 95% CI, 95% confidence intervals.