Research Article
IRF7 Gene Variations Confer Susceptibility to Autoimmune Thyroid Diseases and Graves’ Ophthalmopathy
Table 5
Allele and genotype distribution of IRF7 in AITDs patients with or without early onset age.
| | SNP | Onset age of AITDs patients | | OR (95% CI) | | ≤18 | ≥19 |
| | rs1061501 | — | — | — | — | | AA | 65 (53.3%) | 358 (46.7%) | — | — | | AG | 48 (39.3) | 328 (42.8%) | 0.315 | — | | GG | 9 (7.4) | 81 (10.6%) | — | — | | A | 178 (73%) | 1044 (68.1%) | 0.126 | 1.266 (0.936-1.712) | | G | 66 (27%) | 490 (31.9%) | — | — | | rs1131665 | — | — | — | — | | AA | 115 (94.3%) | 734 (95.7%) | — | — | | AG | 7 (5.7%) | 33 (4.3%) | 0.477 | 0.739 (0.319-1.709) | | GG | 0 (0%) | 0 (0%) | — | — | | A | 237 (97.1%) | 1501 (97.8%) | 0.483 | 0.744 (0.326-1.702) | | G | 7 (2.9%) | 33 (2.2%) | — | — | | rs1061502 | — | — | | | | AA | 115 (94.3%) | 736 (96%) | — | — | | AG | 7 (5.7%) | 31 (4%) | 0.390 | 0.692 (0.298-1.608) | | GG | 0 (0%) | 0 (0%) | — | — | | A | 237 (97.1%) | 1503 (98%) | 0.395 | 0.698 (0.304-1.604) | | G | 7 (2.9%) | 31 (2%) | — | — |
|
|
AITD, autoimmune thyroid disease; OR, odds ratio; 95% CI, 95% confidence intervals.
|
