Research Article
IRF7 Gene Variations Confer Susceptibility to Autoimmune Thyroid Diseases and Graves’ Ophthalmopathy
Table 6
IRF7 genotype and allele distribution in clinical subphenotype of HT patients.
| | SNP | HT | | OR (95% CI) | | Hypothyroidism | Nonhypothyroidism |
| | rs1061501 | — | — | — | — | | AA | 94 (48.5%) | 48 (46.6%) | — | — | | AG | 73 (37.6) | 45 (43.7%) | 0.443 | — | | GG | 27 (13.9) | 10 (9.7%) | — | — | | A | 261 (67.3%) | 141 (68.4%) | 0.770 | 0.947 (0.659-1.361) | | G | 127 (32.7%) | 65 (31.6%) | — | — | | rs1131665 | — | — | — | — | | AA | 187 (96.4%) | 98 (95.1%) | — | — | | AG | 7 (3.6%) | 5 (4.9%) | 0.834 | 1.363 (0.422-4.406) | | GG | 0 (0%) | 0 (0%) | — | — | | A | 381 (98.2%) | 201 (97.6%) | 0.836 | 1.354 (0.424-4.320) | | G | 7 (1.8%) | 5 (2.4%) | — | — | | rs1061502 | — | — | | | | AA | 187 (96.4%) | 98 (95.1%) | — | — | | AG | 7 (3.6%) | 5 (4.9%) | 0.834 | 1.363 (0.422-4.406) | | GG | 0 (0%) | 0 (0%) | — | — | | A | 381 (98.2%) | 201 (97.6%) | 0.836 | 1.354 (0.424-4.320) | | G | 7 (1.8%) | 5 (2.4%) | — | — |
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HT, Hashimoto’s thyroiditis; OR, odds ratio; 95% CI, 95% confidence intervals.
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