Metabolic Effects of Testosterone Hormone Therapy in Normal and Orchiectomized Male Rats: From Indirect Calorimetry to Lipolytic Enzymes

Table 1

Mean ± SD of the biochemical parameters among studied groups (n = 8 per each group).

Parameters	Sham	T-Sham	Orch	T-Orch
Testosterone (ng/ml)	7.01 ± 0.91	14.95 ± 1.69	0.94 ± 0.17	4.41 ± 1.01
		^a	^a	^a
				^b
Ghrelin (pg/ml)	574.58 ± 49.11	748.26 ± 69.14	233.34 ± 38.12	705.26 ± 63.78
		^a	^a	^a
				^b
Growth hormone (pg/ml)	3671.67 ± 382.59	3824.17 ± 271.96	2356.67 ± 671.54	3318.33 ± 714.60
		^a	^a	^a
				^b
Insulin (mIU/l)	8.52 ± 0.16	9.95 ± 1.06	4.49 ± 0.74	7.86 ± 0.38
		^a	^a	^a
				^b
Glucose (mmol/l)	6.03 ± 0.28	5.63 ± 0.41	6.74 ± 0.57	5.88 ± 0.37
		^a	^a	^a
				^b
HOMA-IR	2.29 ± 0.12	2.49 ± 0.31	1.34 ± 0.24	2.05 ± 0.12
		^a	^a	^a
				^b
Cholesterol (mmol/l)	3.91 ± 0.24	8.03 ± 0.62	3.64 ± 0.79	6.92 ± 1.37
		^a	^a	^a
				^b
LDL (mmol/l)	2.29 ± 0.14	4.52 ± 0.62	1.40 ± 0.62	3.83 ± 1.12
		^a	^a	^a
				^b
HDL (mmol/l)	0.86 ± 0.08	2.01 ± 0.22	1.77 ± 0.16	1.80 ± 0.28
		^a	^a	^a
				^b
VLDL (mmol/l)	0.29 ± 0.06	0.57 ± 0.13	0.07 ± 0.01	0.48 ± 0.08
		^a		^a
				^b
TG (mmol/l)	1.44 ± 0.30	2.86 ± 0.64	0.33 ± 0.07	2.38 ± 0.38
		^a	^a	^a
				^b
HSL (pg/ml)	123.84 ± 4.67	107.38 ± 7.67	118.52 ± 3.35	64.56 ± 3.68
		^a	^a	^a
				^b
ATGL (ng/ml)	4.98 ± 0.36	23.21 ± 1.67	7.40 ± 0.53	25.18 ± 1.07
		^a	^a	^a
				^b
FFA (ng/dl)	563.52 ± 6.64	494.34 ± 3.58	569.22 ± 10.56	501.16 ± 7.06
		^a	^a	^a
				^b

Sham = normal control; T-Sham = normal rats treated with IM testosterone undecanoate preparation (100 mg/kg); Orch = orchiectomized rats; T-Orch = orchiectomized rats treated with IM testosterone undecanoate preparation (100 mg/kg); LDL = low-density lipoprotein; HDL = high-density lipoprotein; VLDL = very-low-density lipoprotein; TG = triglycerides; HSL = hormone-sensitive lipase; ATGL = adipocyte triglyceride lipase; FFA = free fatty acids. Significant versus Sham group. Significant versus Orch group.