Research Article
Metabolic Effects of Testosterone Hormone Therapy in Normal and Orchiectomized Male Rats: From Indirect Calorimetry to Lipolytic Enzymes
Table 1
Mean ± SD of the biochemical parameters among studied groups (n = 8 per each group).
| Parameters | Sham | T-Sham | Orch | T-Orch |
| Testosterone (ng/ml) | 7.01 ± 0.91 | 14.95 ± 1.69 | 0.94 ± 0.17 | 4.41 ± 1.01 | | a | a | a | | | | b |
| Ghrelin (pg/ml) | 574.58 ± 49.11 | 748.26 ± 69.14 | 233.34 ± 38.12 | 705.26 ± 63.78 | | a | a | a | | | | b |
| Growth hormone (pg/ml) | 3671.67 ± 382.59 | 3824.17 ± 271.96 | 2356.67 ± 671.54 | 3318.33 ± 714.60 | | a | a | a | | | | b |
| Insulin (mIU/l) | 8.52 ± 0.16 | 9.95 ± 1.06 | 4.49 ± 0.74 | 7.86 ± 0.38 | | a | a | a | | | | b |
| Glucose (mmol/l) | 6.03 ± 0.28 | 5.63 ± 0.41 | 6.74 ± 0.57 | 5.88 ± 0.37 | | a | a | a | | | | b |
| HOMA-IR | 2.29 ± 0.12 | 2.49 ± 0.31 | 1.34 ± 0.24 | 2.05 ± 0.12 | | a | a | a | | | | b |
| Cholesterol (mmol/l) | 3.91 ± 0.24 | 8.03 ± 0.62 | 3.64 ± 0.79 | 6.92 ± 1.37 | | a | a | a | | | | b |
| LDL (mmol/l) | 2.29 ± 0.14 | 4.52 ± 0.62 | 1.40 ± 0.62 | 3.83 ± 1.12 | | a | a | a | | | | b |
| HDL (mmol/l) | 0.86 ± 0.08 | 2.01 ± 0.22 | 1.77 ± 0.16 | 1.80 ± 0.28 | | a | a | a | | | | b |
| VLDL (mmol/l) | 0.29 ± 0.06 | 0.57 ± 0.13 | 0.07 ± 0.01 | 0.48 ± 0.08 | | a | | a | | | | b |
| TG (mmol/l) | 1.44 ± 0.30 | 2.86 ± 0.64 | 0.33 ± 0.07 | 2.38 ± 0.38 | | a | a | a | | | | b |
| HSL (pg/ml) | 123.84 ± 4.67 | 107.38 ± 7.67 | 118.52 ± 3.35 | 64.56 ± 3.68 | | a | a | a | | | | b |
| ATGL (ng/ml) | 4.98 ± 0.36 | 23.21 ± 1.67 | 7.40 ± 0.53 | 25.18 ± 1.07 | | a | a | a | | | | b |
| FFA (ng/dl) | 563.52 ± 6.64 | 494.34 ± 3.58 | 569.22 ± 10.56 | 501.16 ± 7.06 | | a | a | a | | | | b |
|
|
Sham = normal control; T-Sham = normal rats treated with IM testosterone undecanoate preparation (100 mg/kg); Orch = orchiectomized rats; T-Orch = orchiectomized rats treated with IM testosterone undecanoate preparation (100 mg/kg); LDL = low-density lipoprotein; HDL = high-density lipoprotein; VLDL = very-low-density lipoprotein; TG = triglycerides; HSL = hormone-sensitive lipase; ATGL = adipocyte triglyceride lipase; FFA = free fatty acids. Significant versus Sham group. Significant versus Orch group. |