Metformin Counteracts HCC Progression and Metastasis Enhancing KLF6/p21 Expression and Downregulating the IGF Axis

<div>METF action on p21 nuclear translocation: METF stimulated p21 nuclear translocation, confirming that it is able to arrest cell growth by inhibiting cyclin-dependent kinases. These images showed the different localization of the signal in cells treated with METF in respect to MEM control. Scale bars: 200 <i>μ</i>m (20X) and 100 <i>μ</i>m (40X).</div>

International Journal of Endocrinology

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Figure 2

Figure 2: Metformin Counteracts HCC Progression and Metastasis Enhancing KLF6/p21 Expression and Downregulating the IGF Axis 