Metformin Counteracts HCC Progression and Metastasis Enhancing KLF6/p21 Expression and Downregulating the IGF Axis

<div>METF action on antiproliferative marker expression: (a) immunofluorescence data indicated that METF enhanced p21 nuclear translocation, confirming that METF was able to influence the key regulators of cell cycle; (b) immunofluorescence assay showed that METF improved KLF6 protein content after 48 h of treatment. Scale bars: 200 <i>μ</i>m (20X) and 100 <i>μ</i>m (40X).</div>

International Journal of Endocrinology

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Figure 4

Figure 4: Metformin Counteracts HCC Progression and Metastasis Enhancing KLF6/p21 Expression and Downregulating the IGF Axis 