Metformin Counteracts HCC Progression and Metastasis Enhancing KLF6/p21 Expression and Downregulating the IGF Axis

<div>METF action on tumorigenesis marker expression: (a) after 48 h of differentiation, METF treatment could decrease OPN protein expression compared with MEM control; (b) immunofluorescence assay of CK19 after 48 h of treatment showed how METF could decrease CK19 protein expression in respect to MEM control; (c) immunofluorescence assay for annexin A5 after 48 h of treatment revealed that METF was able to increase protein expression in respect to MEM control. Scale bars: 200 <i>μ</i>m (20X) and 100 <i>μ</i>m (40X).</div>

International Journal of Endocrinology

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Figure 6

Figure 6: Metformin Counteracts HCC Progression and Metastasis Enhancing KLF6/p21 Expression and Downregulating the IGF Axis 