International Journal of Endocrinology / 2019 / Article / Tab 2

Research Article

Decreased Serum microRNA-21, microRNA-25, microRNA-146a, and microRNA-181a in Autoimmune Diabetes: Potential Biomarkers for Diagnosis and Possible Involvement in Pathogenesis

Table 2

Association of serum levels of miR-21, miR-25, miR-146a, and miR-181a with clinical parameters in autoimmune diabetes.

miR-21miR-25miR-146amiR-181a

Sex0.024−0.231−0.1500.064
Age0.2690.5760.2600.016
BMI−0.0690.2960.046−0.151
Age of onset0.1920.4830.249−0.026
Duration0.1560.265−0.025−0.100
HbA1c0.079−0.1150.1470.175
FCP−0.106−0.2840.0110.079
2hCP−0.173−0.132−0.0060.045
TC0.021−0.1590.059−0.020
TG−0.093−0.3150.009−0.100
HDL-C0.209−0.0340.026−0.095
LDL-C−0.018−0.2390.0200.053
GADA titers0.006−0.0690.2350.039
ICA titers−0.028−0.152−0.0830.118
IA-2A titers−0.181−0.224−0.0770.116
Number of positive antibodies0.157−0.0580.1250.166

Note: ; . Abbreviations: T1D, type 1 diabetes; LADA, latent autoimmune diabetes of adults; T2D, type 2 diabetes; BMI, body mass index; HbA1c, glycosylated hemoglobin; FCP, fasting C-peptide; 2hCP, 2-h postprandial C-peptide; TC, total cholesterol; TG, total triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; GADA, glutamic acid decarboxylase antibody; IA-2A, protein tyrosine phosphatase antibody; ICA, islet cell antibody.

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