Identification of Serum miRNA-423-5p Expression Signature in Somatotroph Adenomas
Figure 1
MiRNA expression profiling of somatotroph adenomas and healthy pituitary samples. (a): Exosome sequence profiling found 564 miRNAs in somatotroph adenomas and 608 healthy pituitary samples. (b) The volcano plot showed differently expressed miRNAs between somatotroph adenomas and healthy pituitary samples, red point indicated the 121 upregulated miRNAs, and green point indicated the 48 downregulated miRNAs in somatotroph adenomas. Blue point represented the miRNAs that were no difference between somatotroph adenomas and healthy pituitary samples. (c) Cluster analysis of differently expressed miRNAs between somatotroph adenomas and healthy pituitary samples. (d) 511 target mRNAs of hsa-miR-320a and hsa-miR-423-5p were enriched in different signal pathways by KEGG.