Aerobic Training Associated with Arginine Supplementation Reduces Collagen-Induced Platelet Hyperaggregability in Rats under High Risk to Develop Metabolic Syndrome

Figure 5

The hypothesis of inhibitory effect of exercise and arginine association in platelet activation of rats under high risk to develop metabolic syndrome. The high fructose intake triggers several cardiometabolic disorders, reflecting in an increase in lactic acid, proinflammatory cytokines, and oxidative stress. These events contribute to collagen-induced platelet activation. In addition, the increase in lactic acid produced by anaerobic glycolysis in platelets might be a mediator in platelet hyperaggregability. On the other hand, aerobic training associated with arginine supplementation decreases platelet hyperaggregability collagen–induced probably related to enhancement of NO production, inhibition of proinflammatory cytokines and oxidative stress, and finally inhibition of platelet aggregation.