A Novel Pentapeptide Inhibitor Reduces Amyloid Deposit Formation by Direct Interaction with hIAPP

Figure 4

Observation of morphology of hIAPP fibril formation by a transmission electron microscope (TEM). The electron micrographs were taken following incubation for 24 hours at 37°C. The concentration of hIAPP was 10 μM while the concentrations of FLPNF and NFGAIL were 100 μM. Full-length hIAPP fibrils showing typical morphology and formation of dense aggregates. The fibrils of hIAPP incubated with FLPNF were not completely prevented but were reduced in density. No reduction of the fibrils was observed after adding NFGAIL. Scale bar: 200 nm.