Clinical Usefulness of Bioavailable Vitamin D and Impact of GC Genotyping on the Determination of Bioavailable Vitamin D in a Korean Population

Table 4

VDBP, total 25(OH)D, and genotype-independent and genotype-specific bioavailable 25(OH)D concentrations according to the (a) Child-Pugh class in patients with LC and (b) trimester in pregnant women.

(a) Patients with LC

	Child-Pugh class A and B ()	Child-Pugh class C ()	value
VDBP (μg/ml)	91.6 (73.0-119.8)	45.3 (33.4-52.6)	<0.001
Total 25(OH)D (ng/ml)	11.7 (8.2-17.7)	8.6 (5.9-12.6)	0.057
Bioavailable 25(OH)D (ng/ml)
Genotype-independent	2.4 (1.4-4.0)	2.4 (1.2-3.6)	0.866
Genotype-specific	2.9 (1.2-4.4)	3.0 (1.5-4.9)	0.413

(b) Pregnant women

	First and second trimester ()	Third trimester ()	value
VDBP (μg/ml)	341.1 (260.8-386.5)	371.1 (320.2-412.4)	0.213
Total 25(OH)D (ng/ml)	18.2 (12.9-23.5)	16.7 (11.3-23.2)	0.653
Bioavailable 25(OH)D (ng/ml)
Genotype-independent	1.4 (1.1-2.1)	1.1 (0.8-1.7)	0.245
Genotype-specific	1.4 (1.0-2.0)	1.0 (0.8-1.7)	0.469

Values are presented with median (interquartile range). VDBP: vitamin D-binding protein; 25(OH)D: 25-hydroxy vitamin D; LC: liver cirrhosis.