Novel Prognostic Factors Associated with Cell Cycle Control in Sporadic Medullary Thyroid Cancer Patients

Figure 1

Gene and protein expression levels in MTC patients. (a) AURKA (Aurora kinase A gene) expression in 71 MTC patients evaluated by qPCR (TN = normal thyroid). (b) Representative western blot for PTTG1 and AKA (Aurora kinase A) in 6 MTC patients (3: stage I; 4: stage I; 5: stage III; 6: stage IV; 7: stage II; and 8: stage IV), 2 controls (healthy thyroid, numbers 1 and 2), and 1 patient with papillary thyroid carcinoma (number 9). (c) PTTG1 expression in 71 MTC patients evaluated by qPCR (TN = normal thyroid). (d) Spearman’s correlation between PTTG1 and AURKA expression levels for 71 MTC patients evaluated by qPCR. (e) Spearman’s correlation between Ki-67 and PTTG1 expression levels for 54 MTC patients.

(a)

(b)

(c)

(d)

(e)