Monthly Intramuscular Neridronate for the Treatment of Postmenopausal Osteoporosis: Results of a 6-Year Prospective Italian Study

Table 2

General and bone biochemical parameters at baseline.

Parameter	Overall population ()	Reference values
General biochemical parameters
Uric acid (mg/dL)	(3.4-6.6)	<6
Urea (mg/dL)	(17.4-48.9)	12.6-42.6
Creatinine (mg/dL)	(0.46-1.06)	<1.30
Total protein (g/dL)	(5.77-7.84)	6.00-8.20
Fasting plasma glucose (mol/L)	(4.00-5.78)	3.3-6.1
Glycosylated Hb (%)	(5.2-6.8)	4.0-6.0
Total cholesterol (mg/dL)	(160-309)	120-200
HDL (mg/dL)	(41-100)	≥45
LDL (mg/dL)	(79-172)	≤160
Triglycerides (mg/dL)	(35-214)	30-150
Vitamin B12 (pg/mL)	(198-803)	187-883
Folates (ng/mL)	(3.9-13.3)	3.1-20.5
Homocysteine (μmol/L)	(7.6-25.0)	4.4-13.6
Bone biochemical parameters
25(OH)D (ng/mL)	(4.0-45.7)	<10.0 insufficiency,; 10.0-30.0 deficiency; 30.0-100.0 normality
PTH (pg/mL)	(11.8-98.5)	4.4-58.6
T-Ca (mmol/L)	(2.47-2.02)	2.10-2.62
I-Ca (mmol/L)	(1.04-1.40)	1.13-1.32
CTX (ng/mL)	(0.058-0.956)	<0.779
NTX (μg/L)	(1.7-12.2)	2.1-5.6
Osteocalcin (ng/mL)	(3.56-59.2)	5.0-60.0
BAP (μg/L)	(2.7-39.0)	6.0-26.0

Data are expressed as deviation (SD) and range (min-max). Abbreviations: Hb: hemoglobin; HDL: high-density lipoprotein; LDL: low-density lipoprotein; 25-OH-D: circulating vitamin D; PTH: parathyroid hormone, T-Ca: total calcium; I-Ca: ionized calcium; CTX: carboxy-terminal cross-linked telopeptide of type 1 collagen; NTX: amino-terminal cross-linked telopeptide of type 1 collagen; BAP: bone alkaline phosphatase.