Low Frequency of MKRN3 and DLK1 Variants in Chinese Children with Central Precocious Puberty

Figure 1

Location of MKRN3 variants identified in patients with central precocious puberty. Blue boxes, zinc-finger domains; red box, makorin-type Cys-His motif; green box, C3HC4 RING finger motif. Red arrows indicate the locations of all reported variants which will cause nonsense or frameshift variants. Blue arrows indicate the locations of all reported missense variants, and yellow arrows indicate missense variants we found in the present study.