Low Frequency of MKRN3 and DLK1 Variants in Chinese Children with Central Precocious Puberty

Figure 3

MKRN3 protein structure and variants identified in patients with central precocious puberty. Zn, zinc; H, histidine; C, cysteine. The three C3H1 zinc-finger motifs are shown in red, the C3HC4 RING finger motif is in blue, and the makorin-type Cys-His domain is shown in green. The numbers correspond to the amino acid positions in the protein. Red variant labels and arrows indicate the location of the missense variants.