Low Frequency of MKRN3 and DLK1 Variants in Chinese Children with Central Precocious Puberty

Table 1

Clinical and biochemical features of the enrolled patients.

	CPP patients		Early puberty patients
	Boys	Girls	Boys	Girls
Patients (n)	9	164	9	34
Age at diagnosis (years)	8.5 (7.8–8.9)	7.4 (2.4–7.9)	9.4 (9.1–9.9)	8.2 (8.1–8.8)
BMI SD	0.2 (−0.5–2.0)	0.4 (−0.2–1.7)	1.2 (−0.2–2.8)	0.4 (−1.4–4.8)
Height SD	1.2 (−1.8–3.2)	0.6 (0.2–3.4)	1.1 (−2.1–2.8)	0.7 (−0.8–3.1)
Bone age (years)	11.5 (10.8–12.6)	9.3 (4.0–11.5)	12.6 (11.7–13.4)	10.6 (9.9–12.2)
Basal LH (UI/L)	1.05 (0.15–5.8)	0.94 (0.07–2.31)	1.89 (0.89–6.18)	1.02 (0.16–6.32)
Peak LH (UI/L)	18.7 (8.8–27.5)	9.8 (5.8–97.1)	22.6 (13.2–29.0)	11.1 (8.5–65.7)
Peak LH/FSH ratio	1.8 (0.7–2.5)	1.1 (0.6–2.68)	2.6 (1.1–3.8)	1.3 (0.7–3.2)
E2 for girls (pg/ml)		28.3 (16.8–64.2)		48.9 (19.2–59.6)
T for boys (ng/dl)	85.4 (45.6–185.8)		111.4 (49.5–215.3)

Data are shown in median and range. BMI, body mass index; SD, standard deviation; LH, luteinizing hormone; FSH, follicle-stimulating hormone; E2, estradiol; T, testosterone.