Physiological Effect of Ghrelin on Body Systems

Figure 7

Representation of assumed mechanistic pathways involving ghrelin and its respective receptors in hippocampal cells. The intracellular pathways leading to functional outcomes related to memory modulation are shown in red. HIP: hippocampus; MMP: matrix metalloproteinase; LTP: long-term potentiation; ERK: extracellular signal-regulated kinase; CREB: cAMP response element-binding protein; NOS: nitric oxide synthase; PI3K/Akt: phosphatidylinositol 3-kinase and protein kinase B [70].