Physiological Effect of Ghrelin on Body Systems

Figure 9

CNS ghrelin increases adiposity by favoring peripheral lipid deposition. Ghrelin binds to its receptor and hypothalamic neuropeptides (NPY/AgRP vs. POMC), and thereby melanocortin receptors are likely involved in the lipogenic action of ghrelin. Red arrows indicate the hypothetical molecular steps which have not been described for the lipogenic action of ghrelin. POMC: proopiomelanocortin; SCD1: stearoyl-CoA desaturase-1 [161].