The ANGPTL8 rs2278426 (C/T) Polymorphism Is Associated with Prediabetes and Type 2 Diabetes in a Han Chinese Population in Hebei Province
Table 2
Genotype and allele frequencies for the ANGPTL8 rs2278426 (C/T) polymorphism in the study groups.
Genotypes rs659366
Healthy controls (n = 524)
Pre-DM (n = 460)
T2DM (n = 460)
CC
278 (53.1)
208 (45.2)
170 (37.0)
CT
210 (40.1)
202 (43.9)
221 (48.0)
TT
36 (6.8)
50 (10.9)
69 (15.0)
MAF (A-allele), %
26.2
32.9
39.0
PHEW
0.951
0.994
0.990
C
766 (73.1)
618 (67.2)
561 (61.0)
T
282 (26.9)
302 (32.8)
359 (39.0)
(CC + CT) vs. TT (dominant)
—
OR = 0.605 [0.386–0.947]
OR = 0.418 [0.273–0.639]
CC vs. TT (additive)
—
OR = 0.539 [0.339–0.857]
OR = 0.319 [0.204–0.498]
CC vs. (CT + TT) (recessive)
—
OR = 0.73 [0.568–0.939]
OR = 0.519 [0.402–0.67]
CT vs. (CC + TT) (co-dominant)
—
OR = 1.171 [0.908–1.509]
OR = 1.383 [1.074–1.781]
Values are shown as n (%). Pre-DM: prediabetes; T2DM: type 2 diabetes mellitus; MAF: minor allele frequency; CI: confidence interval; OR: odds ratio; HWE=Hardy–Weinberg equilibrium.
