The ANGPTL8 rs2278426 (C/T) Polymorphism Is Associated with Prediabetes and Type 2 Diabetes in a Han Chinese Population in Hebei Province

Table 3

Odds ratios of having each genotype and allele of the ANGPTL8 rs2278426 (C/T) polymorphism in the study groups.

Genotype/allele	Pre-DM vs. control				T2DM vs. control
	P	OR	P^a	OR	P	OR	P^a	OR
rs2278426
CC	—	Reference			—	Reference
CT	0.062	1.286 (0.988–1.674)	0.359	1.143 (0.859–1.522)	0.001	1.721 (1.316–2.251)	0.041	1.384 (1.013–1.890)
TT	0.009	1.856 (1.167–2.954)	0.039	1.696 (1.026–2.802)	0.001	3.224 (2.057–5.052)	0.001	2.530 (1.476–4.334)
C	—	Reference			—	Reference
T	0.004	1.327 (1.093–1.611)	0.034	1.253 (1.017–1.544)	0.001	1.751 (1.447–2.118)	0.001	1.518 (1.214–1.897)

OR: odds ratio; CI: confidence interval; pre-DM: prediabetes; T2DM: type 2 diabetes mellitus. P^a value adjusted for age, sex, and body mass index.