Research Article
The ANGPTL8 rs2278426 (C/T) Polymorphism Is Associated with Prediabetes and Type 2 Diabetes in a Han Chinese Population in Hebei Province
Table 3
Odds ratios of having each genotype and allele of the ANGPTL8 rs2278426 (C/T) polymorphism in the study groups.
| Genotype/allele | Pre-DM vs. control | T2DM vs. control | P | OR | Pa | OR | P | OR | Pa | OR |
| rs2278426 | CC | — | Reference | — | Reference | CT | 0.062 | 1.286 (0.988–1.674) | 0.359 | 1.143 (0.859–1.522) | 0.001 | 1.721 (1.316–2.251) | 0.041 | 1.384 (1.013–1.890) | TT | 0.009 | 1.856 (1.167–2.954) | 0.039 | 1.696 (1.026–2.802) | 0.001 | 3.224 (2.057–5.052) | 0.001 | 2.530 (1.476–4.334) | C | — | Reference | — | Reference | T | 0.004 | 1.327 (1.093–1.611) | 0.034 | 1.253 (1.017–1.544) | 0.001 | 1.751 (1.447–2.118) | 0.001 | 1.518 (1.214–1.897) |
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OR: odds ratio; CI: confidence interval; pre-DM: prediabetes; T2DM: type 2 diabetes mellitus. Pa value adjusted for age, sex, and body mass index.
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