The ANGPTL8 rs2278426 (C/T) Polymorphism Is Associated with Prediabetes and Type 2 Diabetes in a Han Chinese Population in Hebei Province
Table 4
Association of the ANGPTL8 rs2278426 (C/T) polymorphism genotypes with biochemical parameters in the pre-DM group.
Variables
Genotype groups
All values
Pairwise comparisons
CC (n = 208)
CT (n = 202)
TT (n = 50)
P1
P2
P3
Age (years)
52.19 ± 12.75
54.82 ± 11.47
54.94 ± 9.70
0.06
0.077
0.428
1.000
Male/female (n)
94/114
89/113
17/33
—
—
—
—
BMI (kg/m2)
27.00 ± 3.76
27.36 ± 4.24
26.52 ± 3.78
0.362
1.000
1.000
0.548
SBP (mm/Hg)
125.94 ± 12.11
126.19 ± 11.93
125.80 ± 12.12
0.967
1.000
1.000
1.000
DBP (mm/Hg)
76.90 ± 8.57
76.17 ± 8.97
75.34 ± 8.31
0.46
1.000
0.771
1.000
TC (mmol/L)
4.93 ± 0.94
5.01 ± 0.96
4.72 ± 0.90
0.144
1.000
0.516
0.157
TG (mmol/L)
1.62 ± 1.05
1.67 ± 1.14
1.38 ± 0.75
0.213
1.000
0.426
0.237
HDL (mmol/L)
1.31 ± 0.24
1.29 ± 0.25
1.28 ± 0.24
0.692
1.000
1.000
1.000
LDL (mmol/L)
3.06 ± 0.77
3.08 ± 0.77
2.74 ± 0.72
0.017
1.000
0.024
0.018
FPG (mmol/L)
5.69 ± 0.62
5.73 ± 0.48
6.01 ± 0.71
<0.001
1.000
0.001
0.008
PBG (mmol/L)
7.93 ± 1.32
8.39 ± 1.10
8.56 ± 1.79
0.002
0.001
0.006
1.000
FINS (µU/mL)
9.24 ± 3.20
8.59 ± 2.72
7.62 ± 3.81
<0.001
0.095
0.003
0.142
Postprandial insulin (µU/m)
64.53 ± 23.46
64.70 ± 20.76
57.58 ± 22.96
0.109
1.000
0.144
0.131
HbA1c (%)
5.71 ± 0.36
5.79 ± 0.37
5.98 ± 0.57
<0.001
0.139
<0.001
0.007
HOMA-IR
2.34 ± 0.88
2.19 ± 0.73
2.05 ± 1.07
0.049
0.223
0.094
0.903
HOMA-B
92.50 ± 44.07
80.19 ± 31.02
65.25 ± 40.79
<0.001
0.004
<0.001
0.043
Values are shown as mean ± standard deviation. Each group was compared by one-way analysis of variance. values were corrected by a post hoc Bonferroni test. Pre-DM: prediabetes; BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; TC: total cholesterol; TG: triglycerides; HDL: high-density lipoprotein; LDL: low-density lipoprotein; FPG: fasting plasma glucose; PBG: postprandial blood glucose; FINS: fasting insulin; HbA1c: glycosylated hemoglobin; HOMA-IR/-B: homeostasis model assessment-insulin resistance/β-cell function. P1:CT vs. CC; P2:TT vs. CC; P3:TT vs. CT.
