The ANGPTL8 rs2278426 (C/T) Polymorphism Is Associated with Prediabetes and Type 2 Diabetes in a Han Chinese Population in Hebei Province
Table 5
Association of the ANGPTL8 rs2278426 (C/T) polymorphism genotypes with biochemical parameters in the T2DM group.
Variables
Genotype groups
All values
Pairwise comparisons
CC (n = 170)
CT (n = 221)
TT (n = 69)
P1
P2
P3
Age (years)
58.35 ± 11.24
59.14 ± 11.23
60.84 ± 10.24
<0.291
1.000
0.350
0.800
Male/female (n)
71/99
106/115
31/38
—
—
—
—
BMI (kg/m2)
26.91 ± 3.71
27.19 ± 3.82
26.92 ± 3.73
0.745
1.000
1.000
1.000
SBP (mm/Hg)
131.20 ± 11.82
130.60 ± 13.08
131.26 ± 12.50
0.869
1.000
1.000
1.000
DBP (mm/Hg)
78.21 ± 8.97
77.71 ± 8.42
78.03 ± 8.09
0.848
1.000
1.000
1.000
TC (mmol/L)
4.96 ± 1.03
5.01 ± 0.98
5.14 ± 1.19
0.469
1.000
0.657
1.000
TG (mmol/L)
1.86 ± 1.44
1.88 ± 1.38
1.93 ± 1.98
0.950
1.000
1.000
1.000
HDL (mmol/L)
1.29 ± 0.32
1.31 ± 0.28
1.27 ± 0.28
0.505
1.000
1.000
0.825
LDL (mmol/L)
2.86 ± 0.829
2.91 ± 0.83
2.99 ± 0.83
0.526
1.000
0.785
1.000
FPG (mmol/L)
7.28 ± 1.66
7.84 ± 1.53
9.35 ± 2.29
<0.001
0.004
<0.001
<0.001
PBG (mmol/L)
11.86 ± 2.58
12.44 ± 2.64
14.44 ± 2.72
<0.001
0.095
<0.001
<0.001
FINS (µU/mL)
8.17 ± 2.74
7.97 ± 2.72
6.44 ± 2.51
<0.001
1.000
<0.001
<0.001
Postprandial insulin (µU/m)
47.33 ± 15.92
46.35 ± 15.56
48.80 ± 16.90
0.520
1.000
1.000
0.796
HbA1c (%)
7.08 ± 1.36
7.10 ± 1.21
8.75 ± 1.99
<0.001
1.000
<0.001
<0.001
HOMA-IR
2.64 ± 1.05
2.78 ± 1.11
2.72 ± 1.35
0.504
0.726
1.000
1.000
HOMA-B
51.49 ± 27.47
41.57 ± 21.04
26.25 ± 17.07
<0.001
<0.001
<0.001
<0.001
Values are shown as means ± standard deviation. Each group was compared by one-way analysis of variance. values were corrected by a post hoc Bonferroni test. T2DM: type 2 diabetes mellitus; BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; TC: total cholesterol; TG: triglycerides; HDL: high-density lipoprotein; LDL: low-density lipoprotein; FPG: fasting plasma glucose; PBG: postprandial blood glucose; FINS: fasting insulin; HOMA-IR: homeostasis model assessment-insulin resistance; HOMA-B: β-cell function. P1:CT vs. CC; P2:TT vs. CC; P3:TT vs. CT.
