Ultrasound Real-Time Tissue Elastography Improves the Diagnostic Performance of the ACR Thyroid Imaging Reporting and Data System in Differentiating Malignant from Benign Thyroid Nodules: A Summary of 1525 Thyroid Nodules
Table 4
Diagnostic performance of RTE, TI-RADS, or both in 1525 nodules.
Size interval (cm)
AUC (95%CI)
Sensitivity (%)
Specificity (%)
Accuracy (%)
PPV (%)
NPV (%)
0 < D ≤ 0.5
TI-RADS
0.916 (0.815–1.000)
89.7
87.5
91.89
91.94
91.67
RTE
0.832 (0.714–0.950)
74.1
81.2
75.67
93.48
46.43
TI-RADS plus RTE
0.941 (0.861–1.000)
94.8
87.5
93.24
96.49
82.35
0.5 < D ≤ 1.0
TI-RADS
0.903 (0.871–0.935)
87.9
85.3
89.20
87.03
94.30
RTE
0.943 (0.920–0.966)
90.0
93.9
91.48
96.13
84.86
TI-RADS plus RTE
0.961 (0.941–0.982)
90.0
93.9
91.29
97.03
83.56
1.0 < D ≤ 2.0
TI-RADS
0.894 (0.869–0.919)
85.0
88.1
83.08
73.11
93.02
RTE
0.954 (0.937–0.970)
94.1
94.4
94.27
91.81
95.97
TI-RADS plus RTE
0.972 (0.960–0.985)
94.3
95.6
94.41
92.12
95.98
2.0 < D ≤ 2.5
TI-RADS
0.942 (0.912–0.973)
86.3
92.9
88.94
94.69
82.11
RTE
0.919 (0.881–0.956)
79.0
96.4
86.06
97.03
75.70
TI-RADS plus RTE
0.971 (0.951–0.990)
89.5
95.2
91.83
96.52
86.02
Note. Unless otherwise indicated, the data point is percentage, and the number in parentheses is 95% CI. PPV = positive predictive value; NPV = negative predictive value.
