Increased DHEAS and Decreased Total Testosterone Serum Levels in a Subset of Men with Early-Onset Androgenetic Alopecia: Does a Male PCOS-Equivalent Exist?
Table 2
Clinical features and serum hormone levels in patients with early-onset androgenetic alopecia (AGA) and in controls.
Parameter
Patients with AGA: n = 43
Group 1a: n = 21
Group 2b: n = 22
Control subjects: n = 36
Age (year)
24.3 (3.4)
24.0 (3.9)
24.5 (2.8)
23.3 (2.7)
BMI (kg/m2)
25.5 (3.8)
27.9 (3.8)
23.0 (1.6)
23.7 (3)
Fat mass (%)
15.6 (4.8)
17.5 (4.1)d
12.4 (4.7)
13.2 (5.3)
Cholesterol (mg/dl)
167.5 (31.4)
163.6 (35.4)
171.2 (27.8)
170.1 (38.2)
HDL cholesterol (mg/dl)
49.2 (13.3)
45.4 (10.9)
52.7 (14.6)
47.7 (9.1)
LDL cholesterol (mg/dl)
104.4 (25.0)
101.7 (28.5)
106.9 (21.9)
100.4 (45.6)
Triglycerides (mg/dl)
69.9 (38.5)
82.5 (46.0)b
58.1 (26.1)
68.7 (35.6)
Glycaemia (mg/dl)
84.4 (8.0)
85.1 (8.9)
83.7 (7.1)
83.8 (6.1)
Insulin (μU/ml)
8.8 (6.2)
11.8 (7.7)†
6.0 (2.1)
7.3 (3.2)
HOMA index
1.9 (1.4)
2.5 (1.8)
1.3 (0.5)
1.5 (0.7)
LH (mIU/ml)
4.3 (1.8)
4.9 (2.1)†
3.8 (1.4)
3.9 (2.2)
FSH (mIU/ml)
3.1 (2.0)
3.1 (1.8)
3.2 (2.2)
3.3 (2.5)
TT (ng/ml)
5.8 (1.71)b
5.2 (1.7)
6.3 (1.6)
6.5 (2.0)
17β-Estradiol (pg/ml)
24.5 (9.6)
22.9 (10.4)
26.0 (8.7)
25.6 (7.7)
Androstenedione (ng/ml)
2.5 (1.1)
2.6 (1.2)
2.4 (1.0)
2.3 (0.9)
DHEAS (μg/dl)
304 (17.1)d
321.5 (112.6)
290.3 (97.0)
257.8 (107.1)
17αOH-P (ng/ml)
2.1 (0.9)
2.0 (1.1)c
2.1 (0.7)
1.5 (0.6)
Cortisol (nmol/l)
429.6 (125.3)
429.8 (132.9)
429.3 (120.4)
383.1 (119.0)
SHBG (nmol/l)
32.9 (10.3)
28.9 (9.7)d
36.6 (9.9)
34.7 (13.7)
Bio-T (%)
44.8 (8.1)
46.9 (7.6)
43.0 (8.4)
45.3 (11.1)
Free-T
1.8 (0.4)
2.0 (0.3)
1.7 (0.4)
1.8 (0.5)
Abbreviations: 17αOH-P = 17α-hydroxyprogesterone; Bio-T = bioavailable testosterone; BMI = body mass index; Free-T = free testosterone; FSH = follicle-stimulating hormone; LH = luteinizing hormone; SHBG = Sex hormone-binding globulin; TT = total testosterone. aPatients with early-onset AGA with at least one of the following parameters: body mass index (BMI) >25 kg/m2, insulin-resistance (IR), and/or sex hormone-binding globulin (SHBG) <25 nmol/l. bPatients with early-onset AGA which did not satisfy any of the aforementioned criteria. compared to controls; compared to Group 2; compared to controls; compared to Group 2 (Student’s t-test). Results are expressed as mean value (standard deviation).
