Rare Somatic MEN1 Gene Pathogenic Variant in a Patient Affected by Atypical Parathyroid Adenoma

Figure 2

(a) Parathyroid adenoma: on hematoxylin-eosin tissue sections, the pushing growth pattern of the tumor and the strict adherence to thyroid tissue is observed. (b). Reduction of nuclear immunoreactivity of menin protein was observed in the neoplastic cell. (c). High-power view (X30) highlights decreased menin expression in neoplastic cells, whereas entrapped parathyroid normal cells maintain strong nuclear menin immunoreactivity.

(a)

(b)

(c)